Industries-PharmaceuticalsWith the development of new medications and treatments, there is a great deal of testing that needs to be done before the product can go to market. Knowledge of material properties can be critical to knowing how a pharmaceutical product will work. Professional reports with accurate results offered by Ebatco can determine if your manufacturing process is producing the ideal end result.

Ebatco offers a multitude of mechanical testing instruments that will meet customer needs when testing or verifying pharmaceuticals. With our instruments, multiple tests can be completed including particle sizing, density and surface tension can be measured, and lifespan testing using thermal degradation and decomposition instrumentation. With Ebatco, you can rest assured that you will be getting accurate results to guarantee that your company develops the ideal pharmaceutical.

Our highly skilled scientists will ensure that every pharmaceutical has the desired material characteristics. It is essential that the pharmaceutical product has every test done before entering a clinical trial because any mistakes on the manufacturer’s part can yield extraordinary consequences. If you have any questions about the services or instrumentation available at Ebatco, feel free to call or email and a member of our team will be able to further assist you.

Applications:

Analysis of particle size for drug particles Density, surface tension, viscosity of liquids Determination of zeta potential for drug particles Investigation of drug particle contact angle Litigation support for patent infringement
Thermal degradation and decomposition        

 

For more information please read our application notes:
Advancing, Receding and Roll-off Angle Measurements through Sliding Angle Method
Coefficient of Thermal Expansion Measurement using TMA
Concentration and Size of Particles in a Diamond Polishing Slurry
Glass Transition Temperature Measurements Using Dynamic Mechanical Analysis
In-situ and Small-Volume Fracture Toughness Measurement via Nanoindentation
Low Vacuum SEM Analysis of Biological Sample – Goldenrod Flower
Melting Temperature and Latent Heat of Fusion of Indium
Micro Contact Angle Measurements on Single Particles, Filaments and Patterned Surfaces
Nanoparticle Sizing through Dynamic Light Scattering
Optical Inspection and Profiling of Defects on a Coated Wafer Surface
Simultaneous Thermal Analysis of the Decomposition of Calcium Oxalate
Specific Heat Capacity of Refractory Material
Surface Free Energy Analysis of Gelatin Samples
Thermogravimetric Analysis of Calcium Oxalate
Zeta Potential of Silica Slurry as a Function of pH
Zeta Potentials of Solid Surfaces

 

Surface Free Energy Analysis of Gelatin Samples

 

Contact angle measurement can provide useful information about the wetting characteristics of a surface and a liquid. Further, by using different probe liquids with known polar, non-polar, hydrogen-bond energy components, the surface free energy of a solid surface can be determined through contact angle measurement. Surface free energy is the excessive energy existing on the surface of a solid due to imbalanced intermolecular forces among molecules of the solid. The surface free energy provides a more general characterization of a surface chemically and energetically and its analysis is of significance to numerous applications such as wetting, cleaning, contamination, adhesion, friction, lubrication, and wear. For instance, with measured surface free energy values for any pair of solids or solid and liquid the work of adhesion between the two can be analyzed through the Young-Dupré theory.

 

appnote-114

 

Table 1 presents the surface free energy analysis performed on two gelatin samples using the Kyowa contact angle meters equipped in our lab. Kyowa Interface Science’s contact angle measurement analysis software, FAMAS, supports five popular surface free energy analysis models. These models include Fowkes’ acid-base, Kitazaki-Hata, Owens-Wendt, Kaelble-Uy, and Wu Model. Each of the five models determines the same or different components that comprise the total surface free energy. As shown in Table 1, the Kaelble-Uy, Wu and OwensWendt models determine the values for each of the components. Because each model has its own assumptions and limitations there is not one that can be universally applicable to all surfaces and probe liquids. Sometimes a particular model will yield useful data and other times it will not based on the combination of solids and probe liquids chosen. In spite of that scientists and engineers may need to work with more than one model, surface energy analysis through contact angle measurement remains a favorite and popular choice for its component level analysis capability and easy of operation.